TABLE OF CONTENTS
CHAPTER ONE
1.1 Introduction
1.2 Historical Perspective of Bacterial Toxin
CHAPTER TWO
2.1 Toxins as Unique Enzymes with Complex Architecture
2.2 Shiga toxins and other bacterial toxins
CHAPTER THREE
3.1 Mode of Action of Bacteria Toxin
3.2 Toxins Targeting Actin and Small Rho Gtpases
3.3 Toxins Corrupting Ubiquitin and Ubiquitin-Like Signaling
3.4 Toxins Targeting Cell Translational Machinery
3.5 Toxins Targeting Snare Machinery
3.6 Toxins Targeting DNA and Inducing ER Stress Responses
3.7 Toxins Targeting cAMP Signaling Components
CHAPTER FOUR
4.0 Toxin Therapeutics
4.1 Bacterial Protein Toxins as Toxoid Vaccine
4.2 Role of Toxin as Immunotoxins in Treatment of Cancer
4.3 Diphtheria Toxin (DT) Based Immunotoxin
4.4 Pseudomonas Exotoxin A-based Immunotoxins
4.5 Anthrax Toxin Based Immunotoxins
4.6 Botulinum Toxin Based Therapeutics
4.6.1 Dermatological use of Botulinum toxin:
4.6.2 Non-dermatological use of Botulinum toxin:
4.3 Conclusion
REFERENCES
