40 Pages, Chapter 1-5
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TABLE OF CONTENTS
CHAPTER ONE
1.1 Introduction
1.2. Secondary Metabolites
CHAPTER TWO
2.0 Screening for Secondary Metabolites of Microorganisms
2.1 Primary Screening
2.1.1 Chemical Screening
2.1.2 Biological Screening
2.1.3 Pharmacological Screening
2.2 Secondary Screening
2.2.1 Isolation of the Pure Substances
2.2.2 Structural Determination of the Isolated Metabolites
2.2.3 Pharmacological Investigation of the Isolated Metabolites
2.2.4 Modification of the Isolated Secondary Metabolites
2.3 Manipulations of Microorganisms for the Production of Secondary Metabolites
2.3.1 Types of Regulation Found In Secondary Metabolism
2.3.1.1 Regulation by Medium Composition
2.3.1.2 Biochemical Regulation
2.3.1.3 Genetic Regulation
2.4 Approaches to the Manipulation of Secondary Metabolites. Why Manipulate?
2.4.1 Strain Improvement
2.4.1.1 The Generation of Altered Genotypes
2.4.2 Recognition and Isolation of Desired Genotypes; Screening.
2.4.3 Production of selected secondary metabolites in transformed bacterial cells.
CHAPTER THREE
3.0 Microorganisms as Source of Secondary Metabolites
3.1 Bioactivities of Microbial Secondary Metabolites
3.2 Specific Features of Microbial Metabolites
3.3 Fungal Secondary Metabolites against Plant Diseases
3.4 Fungal Secondary Metabolites as Insecticidal Compounds
3.5 Fungal Secondary Metabolites as Antibiotics
3.6 Fungal Secondary Metabolites as Antimicrobial Agents
CHAPTER FOUR
4.0 Secondary Metabolites Production by Solid State Fermentation
4.1 Secondary Metabolites and Growth
4.2 Solid State Fermentation (SSF)
4.2.1 Environmental Factors
4.3 Respiration Studies
CONCLUSION
REFERENCES
LIST OF TABLES
1 Biological activity of some microbial secondary metabolites of industrial importance
2 Secondary Metabolites Produced by Solid State Fermentation System
